界面新闻记者 | 陈杨

界面新闻编辑 | 谢欣

10yue8ri，gangguchuangxinyaogongsixindashengwuyuagushangshigongsiaosaikangyaoyegongtongxuanbu，shuangfangjiulietinipian（shangpinming：aoyixin）dachengdujiashangyehuahezuo。

qizhong，aosaikangweilietinideshangshixukechiyouren，fuzegaichanpindeshangyehuashengchanhegonghuo，bingxiangxindashengwuzhifuxiaoshoutuiguangfuwufei。xindashengwuzequdelietinizaizhongguodaludiqudedujiatuiguangxiaoshouquan，bingxiangaosaikangzhifushoufukuan、zhucelichengbeihexiaoshoulichengbeikuanxiang。buguo，shuangfangweipilubencihezuodejutijiaoyijine。

shijishang，jinsanniandexingyehandongshiguoneichuangxinyaolingyufengongquyumingque，yuelaiyueduoguochanchuangxinyaodeshangyehuahuanjiebeijiaojiyouxiaoshoutuanduihejingyande“dachang”laizuo。houzheyejiecijiangzijideshangyehuanenglibianxian，bingfengfuzishendechanpinzuhe。bencixindashengwuheaosaikangdehezuoyeshiruci。

jutidaochanpinshang，lietinishiyikuandisandaiegfr tki（biaopishengzhangyinzishoutilaoansuanjimeiyizhiji）baxiangyao，yeshiaosaikangjinzhanzuikuaide1leixinyao。

muqian，gaiyaoyiyouliangxiangxinyaoshangshishenqing（nda）zaiguojiayaojianju（nmpa）shenpingzhong，fenbieweiegfr tkinaiyaobingcunzaiegfr t790mtubianyangxing、huoyuanfaxingegfr t790mtubianyangxingdefeixiaoxibaofeiai（nsclc）erxianzhiliao，yijiegfrwaixianzi19queshi（19del）huowaixianzi21zhihuantubian（l858r）densclcyixianzhiliao。

qizhong，qianzheyu2021nian11yuehuoshouli，bingyibuchongdijiaoziliao；houzheyu2024nian8yuehuoshouli。aosaikangyujigaiyaojiangyu2024nianhuopi。

zuoweihuanzheduo、shichangdadedaaizhong，wanqinsclcsulaishizhongduoyaoqide“bizhengzhidi”。

zheileihuanzhedexitongxingquanshenzhiliaofenzuoqudongjiyinyinxingheyangxinglianglei。qianzhedangxiadeyixianbiaozhunliaofashipd-1+hualiao。houzhezhong，egfr、krastubianjunshichangjiandequdongjiyintubian，liangzhezainsclchuanzhezhongdexiedailvjunyuewei30%。

zaiegfrtubiannsclczhong，egfr tkiyishiyixianbiaozhunliaofa。youyinweijiejueleqiandaichanpindenaiyaoxingwenti，disandaiegfr tkichengweizhuliuyongyao。2021nian，shoukuansandaichanpinaoxitini（asilikang）jichuangxiachao50yimeiyuandequanqiuxiaoshoue。

zaizheiyishiyingzhengshang，guoneiduojiayaoqidekaifasilujunshiconghouxianwangyixianzhiliaoshangtuijin、jinyibaofangliang，bingtansuolianheyongyao，lietiniyebuliwai。

buguodangxia，gailingyuyixiangdangyongji。zailietiniqian，yiyou6kuandisandaiegfr tkizaiguoneihuopi。

其中，先行者阿美替尼（翰森）、伏美替尼（艾力斯）shangshihouxunsuqiangshiaoxitinishichang，2023nianxiaoshouefenbiechao30yiyuan、yue20yiyuan。

随后，贝福替尼（贝达/益方）、瑞齐替尼（倍而达药业）、瑞厄替尼（圣和药业）先后进场。该品种的价格较量也成为2024年国谈的看点之一。

换而言之，利厄替尼上市即面临激烈竞争。由此，对以消化领域产品起家、zhengzaichuangxinzhuanxing、weiyouzhongliuxinyaoxiaoshoujingyandeaosaikangeryan，jiangqijiaojixindashengwulaimaibunanlijie。yuzhileisidehaiyou，beierdayejiangruiqitiniguoneideshangyehuaquanyishouyulelaopaiyaoqishiyao。

erduixindashengwulaishuo，jieqianjiniandechuangxinyaozibenrelang，gongsiyizhujiancongbiotech（shengwukejigongsi）fazhanchengbiopharma（shengwuzhiyaogongsi）。muqian，qiyongyouyue3000rendexiaoshoutuandui，qieshangyehuanenglizaiguoneiyizhongchuangxinyaogongsizhongpoweituchu。

youci，bang“xinren”maiyaoyeshuidaoqucheng。erchuleshangyehuashouyi，lietiniyebuchonglexindazijizaifeiailingyudebuju。

shijishang，xindashengwuzaizhenggefeiaishangluozipoduo，baokuoyihuopidexindilidankang（pd-1，kuohaoneiweibadian，xiatong）、beifazhudankang（vegr）、saiputini（ret）、fuzeleisai（kras g12c），yijindazhengzaishenpingzhongdetaleitini（ros1）。

qizhong，zaiqudongjiyinyinxingdensclcshang，jishixingchanpinxindilidankangyihuopiyuhualiaolianyong，yongyuyixianzhiliaolinzhuanghefeilinzhuangnsclc。beifazhudankangyuhualiaolianyongyehuopiyongyufeilinzhuangnsclcdeyixianzhiliao。

qudongjiyinyangxingdensclczhong，xindabenshenzaiegfrtubianshangyiyouliaofahuopi，jixindili+beifazhu+hualiaosiyaolianyong，yongyuegfrtubiannsclcdeerxianzhiliao。

不过，相较于后来的新疗法如PD-1/VEGF双抗（依沃西单抗，康方）、egfr/c-metshuangkang（aiwantuodankang，qiangsheng）、trop2 adcdengyaowuyongyuegfrtubiannsclchouxianzhiliao，xindadelianyongfanganzailiaoxiao、yongyaofudandengfangmiandouxianyouyoushi。

lingwai，aiwantuodankangyudisandaiegfr tkilazetinilianyong，zaiquanqiu3qilinchuangtouduitoushiyanzhongjibaiaoxitini，yu2024nian8yuezaimeihuopiyongyuegfrtubiannsclcyixianzhiliao，yexianshichuegfr tkidelianyongqianli。

zheihuodouchengweixindaxuyaoyikuanjijianghuopideegfr tki，laiweichizijizaigailingyudiweideyuanyin。

ciwai，fuzeleisaishiguoneishougehuopidekrasbaxiangyao，zheilingxindazailingyichangjiandequdongjiyinkrastubianshangzhanjuxianfayoushi。retheros1tubianzainsclchuanzhezhongzejiaoweihanjian。

lingwai，lietinibingfeiaosaikangzaifeiailingyubujudeweiyixinyao，qihaiyouyikuanxiaofenzic-metyizhijiaskc202，niyulietinilianyong，zhiliaoegfr-tkinaiyaoqiecunzaimetjiyinyichanghuodanbaiguobiaodadensclchuanzhe。muqian，gailianyongfanganzhengchuyulinchuang1qijieduan。

zheihuoyeshibencixindajinqudelietinishangyehuaquanyi，erfeimaiduangaichanpindeyuanyin。weilai，aosaikanghexindashengwuzaifeiaishangdehezuoshifouhuigengjinyibuhaiyoudaiguancha。