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IPO雷达|创新药企维立志博拟赴港上市:两年半累亏逾8亿元,报告期内仅神州百济一家客户

zichengliyilai,gaigongsilianxu8lunrongzi,hejirongde10.84yiyuanzijin。

图片来源:界面图库

界面新闻记者 | 郭净净

jinqi,nanjingweilizhiboshengwukejigufenyouxiangongsi(jiancheng“weilizhibo”)dijiaogangjiaosuozhubaniposhangshishenqingcailiaohuoshoulibingpilu。12yue8ri,gongsixuanbu,jinyibuweirenzhaoyinguojirongziyouxiangongsiweiqizhengtixiediaoren。

weilizhibocheng,gongsicicigangguipomuzijiangyongyugongsilinchuangjieduanhouxuanyaowuzhengzaijinxingjijihuajinxingdelinchuangkaifajijianguanshiwu,biruhexinchanpinlbl-024dechixulinchuangkaifajijianguanshiwutigongzijin;weigongsiguanxianzhongqitalinchuangjieduanhouxuanyaowu(tebieshizhuyaochanpinlbl-034)dechixulinchuangkaifajijianguanshiwutigongzijin;tuijinjikuozhanxianyouguanxianjiyouhuajishupingtai;jiangyuhouxuanyaowuhuopizhunxiaoshouhouyongyuqishengchan、xiaoshoujishichangtuiguang;yongyuyingyunzijinjiyibanqiyeyongtu。

旗下12项创新候选药物均处于临床阶段

weilizhiboyu2012nianchengli,shiyijialinchuangjieduanshengwukejigongsi,zhiliyuzaizhongliu、zishenmianyixingjibingjiqitazhongdajibingfangmiandechuangxinliaofafaxian、kaifajishangyehua,gongsiyijianlicongzaoqishaixuanjifaxian、linchuangqianyanjiu、linchuangkaifa、cmcdaozhongshishengchandezhenggeyaowukaifaguochengzhongdesuoyoujibengongneng。

zhaogushuxianshi,weilizhibochuangxinguanxianbaokuo12xiangzhuyaozichan(chuangxinhouxuanyaowu),qizhong6kuanyijinrulinchuangjieduan,baokuo1kuanhexinchanpinji3kuanzhuyaochanpin;fenbieweizhenduizhongliude3kuandankelongkangti、4kuanshuangteyixingkangti、2kuankangtioulianyaowu(adc)ji1kuanshuangteyixingronghedanbai,yijizhenduizishenmianyixingjibingde1kuanshuangteyixingronghedanbaiji1kuansanteyixingkangti。

zaizhei12kuanchuangxinhouxuanyaowuzhong,6kuanyichenggongjinrulinchuangjieduan,gaigongsizhengdandujinxinghegong10xianglinchuangxiangmupinggu。qijinweizhi,gongsiyou2kuanhouxuanyaowuyu3zhongshiyingzhengdeiiqilinchuangshiyanzhonghuodegainianzhengming,qiegaidenghouxuanyaowuzhongyou1kuanjinzhanzhiguanjianxinglinchuangshiyanjieduan。

图片来源:维立志博港股招股书

qizhong,weilizhibodehexinchanpinlbl-024shiyikuanchuyuguanjianxinglinchuangjieduandexinxingpd-l1yu4-1bbshuangteyixingkangti。gongsimuqianzhengzaipinggulbl-024(zuoweidanyaoliaofajilianheliaofayibufen)duiyuzhiliaowanqifeiwaishenjingneifenmiai、xiaoxibaofeiai、dandaoai、feixiaoxibaofeiaijiqitashitiliudeliaoxiao。

gaigongsitoulu,lbl-024yiyu2024nian7yuejinruzhenduifeiwaishenjingneifenmiaidedanbeiguanjianxinglinchuangshiyan,shiquanqiudadaoguanjianxinglinchuangshiyanjieduandeshoukuan4-1bbbaxianghouxuanyaowu。lbl-024yiyoukenengchengweizhiliaofeiwaishenjingneifenmiaideshoukuanhuopiyaowu。

ciwai,weilizhiboyu2024nian10yueziguojiayaopinjianduguanliju(nmpa)huodelbl-024zhiliaohouxianfeiwaishenjingneifenmiaidetupoxingliaofarending(btd),bingyu2024nian11yuezimeiguoshipinyaopinjianduguanliju(fda)huodelbl-024zhiliaoshenjingneifenmiaidegueryaorending(odd)。

gaigongsijihuajinyibuyanjiuqiduiqitayaowukuifadeaizhengshiyingzhengdezhiliaoqianli,lirushiguanlinzhuangxibaoai、weiaijiganxibaoai。jiuyouguanguanjianxinglinchuangshiyandelinchuangjinzhanerding,gongsiyouwangzhi2026niandisanjiduxiangnmpatijiaoshengwuzhipinxukeshenqing(bla),yujizhi2027niandierjiduhuodeyoutiaojianpizhun。

weilizhibozhuyaochanpinlbl-033weitongshibaxiangmuc16jicd3deshuangteyixingtxibaoxianjiekangti。gaichanpinzhengbeikaifayongyuzhiliaomuc16gaobiaodadeshitiliu,tebieshiluanchaoai、gongjingaijizigongneimoaidengfukeaizheng。genjufuruositeshaliwenziliao,lbl-033yijishenquanqiujinyoudeliangkuanyijinrulinchuangjieduandemuc16/cd3shuangteyixingkangtizhilie。gongsifenbieyu2023nian2yueji2023nian6yuehuodenmpajifdadeindpizhun,yu2023nian4yuezaizhongguokaizhanlbl-033danyaoliaofazhiliaowanqishitiliudei/iiqiyanjiu。

lingjujieshao,weilizhibodelingyizhuyaochanpinlbl-007weibaxianglag3dequanrenyuanigg4dankelongkangti。genjufuruositeshaliwenziliao,gaichanpinweiquanqiulinchuangjinduqiansandebaxianglag3delinchuangjieduandankelongkangtizhiyi(weiyishangshidelag3baxiangyaowuchuwai),yiweitongleikangtizhongshoukuanbeizhengshiduibiyanaiyouxiaodekangti。

积极商业化变现,签约百济神州等3家公司

weilizhibozhichu,suizhegongsihouqilinchuangzichanjiejinshangyehuashangshi,qikenenghuikaolvjianlijushangyeguimodeshengchansheshi,bingtouguohezuojineibuxiaoshoutuanduijiaqiangshangyehuanengli。tebieshi,gongsizhengzaijijixunqiuyutoubuxingyecanyuzhejichuangyetouzijianlizhanlvehezuohuobanguanxi,yitansuozhongguoyiwaidelinchuangkaifajishangyehuajihui。muqian,gaigongsiyijingyubaijishenzhou、hangzhoubaikaishengwuyiyaoyouxiangongsi、oblenio bio,inc.dengdinglihezuoxieyi。

yu2021nian12yue,weilizhiboyubaijishenzhoudinglishouquanjihezuoxieyi。gaigongsiyishouyubaijishenzhouzaidazhonghuaquyiwaikaifa、shengchanjishangyehualbl007dedujiaxuke,daijiaweizongjigaoda7.72yimeiyuandeshoufukuanjilichengbeifukuan,lingjiashuangweishubaifenbidefenjitexuquanshiyongfei。tongguoyubaijishenzhouhezuo,lbl-007muqianzhengyuzhongguojiquanqiujiuduozhongaizhengshiyingzhengjinxingiiqilinchuangshiyan,baokuofeixiaoxibaofeiai、jiezhichangai、toujingbulinzhuangxibaoai、shiguanlinzhuangxibaoaijibiyanai。

lingjuweilizhibojieshao,yu2023nian4yue,gaigongsiyuaizhengchuangxinadcyaowugongsihangzhoubaikaishengwuyiyaoyouxiangongsi(liantongqiruoganhaiwailianshugongsi,tongcheng“baikaiyiyao”)dingliadchezuokaifaxieyi,yiliyongbaikaiyiyaozhuanyoudeadcyouxiaofuzailianjieqipingtaijixiangguanzhuanyoujishu,gongtongkaifalbl-013jiqitaliangxianglinchuangqianadczichan。

yu2024nian11yue,weilizhiboyushengwujishufengxiantouzigongsioblenio bio,inc.dinglihezuo、dujiaxuanzequanjixukexieyi。gongsiyiyiyuaditum biojiuxinchenglideyijiameiguogongsinewco,zhiliyugongsitedingsanteyixingtcellengagerdequanqiukaifajishangyehuadachenghezuoanpai,jiaoyizongjiazhigaoda6.14yimeiyuan,lingjiaqianzaizhonggeweishutexuquanshiyongfeijiyunewcodeguquan。genjuxieyi,weilizhiboshouyunewcoqilinchuangqianzichanlbl-051(yikuancd19/bcma/cd3 tcellengager)dujiaquanqiuxuke,newcokexuanzeyushiyongxuanzeqihouxingshiqixuanzequanbaoliuyouguanxuke。

两年半累亏8.23亿元,成立以来募资10.84亿元

weilizhibomuqianbingwuchanpinhuozhunjinxingshangyexiaoshou,yiweizichanpinxiaoshouchanshengrenheshouru。yuwangjijiluqijian,gaigongsishangweiludeyingli,bingcunzaiyingyunkuisun。caiwushujuxianshi,2022nian、2023nianji2024nianqian6yue,weilizhiboqineikuisunfenbieshi2.81yiyuan、3.62yiyuanji1.8yiyuan,liangnianbanleijikuisun8.23yiyuan。

图片来源:维立志博港股招股书

yuwangjijiluqijian,gaigongsijinyoubaijishenzhouyimingkehu;yu2023nian,genjubaijishenzhouxieyi,gongsijiujinxingyouguanqiaojieyanjiuzibaijishenzhoushoudaokuanxianggong890wanyuan。yu2022nianhuojiezhi2024nian6yue30rizhiliugeyue,gongsibingwuchanshengrenheshouru。

weilizhibobiaoshi,qiyuhendachengdushangyilailinchuangjieduanjilinchuangqianjieduanhouxuanyaowudechenggong。tanggongsiwufachenggongwanchenglinchuangkaifa、qudejianguanpizhunjishixianhouxuanyaowushangyehua,huotangyujinxingrenheshangshushixiangshizaoyuzhongdayanwuhuochengbenchaozhi,gongsideyewu、caiwuzhuangkuang、jingyingyejijiqianjingjianghuiyanzhongshousun。

gaigongsiyuqijiezhi2024nian12yue31rizhiniandujiangjixuludekuisunjinge。weilizhibobiaoshi,yujiyukeyujianweilaijiangjixuchanshengkuisunjinge,qiekenengwufachanshengchongzushouruyishixianhuoweichiyinglinengli;weilaijingkuisundejinejiangbufenqujueyuyanfaxiangmusuochanshengdechengbenjiyuyingyunyouguandekaizhidaozhideweilaizhichu、renhehuopichanpindeshangyehuachengben、chanshengshourudenengliyijigongsiyuhuotouguoyudisanfangdeanpaizuochuhuoshouqudelichengbeijiqitafukuandeshijianjijine。

2022nian、2023nianji2024nianqian6yue,weilizhibodeyanfakaizhifenbieshi1.85yiyuan、2.31yiyuan、8399.9wanyuan,qizhonghexinchanpinyingzhandeyanfakaizhifenbiewei1390wanyuan、6870wanyuan、3360wanyuanji2700wanyuan,fenbiezhantongqizongjingyingkaizhide6.7%、25.6%、25.4%ji18.9%。

lingjuzhaogushu,2022nian、2023nianji2024nianqian6yue,weilizhibodeliudongfuzhaizongefenbieshi12.26yiyuan、13.95yiyuanji2.18yiyuan,qimoxianjinjixianjindengjiawufenbieshi2.53yiyuan、2.48yiyuanji2.74yiyuan,jingyinghuodongsuoyongxianjinjingefenbiewei4369.2wanyuan、1.93yiyuanji1.07yiyuan。

zichengliyilai,gaigongsilianxu8lunrongzi“buxue”,hejihuodemuzi10.84yiyuan,touzisuodekuanxiangde80.8%yihuodongyong,yinruenranchuangtou、hankangziben、zhengxinguziben、huaigeziben、xinxiwangyiliao、shenchuangtou、kunyaojituandengtouzizhe。gongsiyu2024nian11yuezuixinrongzihoudetouhouguzhiyuewei31.3yiyuan。

jiezhizuihoukexingriqi,weilizhibogongtongchuangshirenkangxiaoqiang、laishoupengjigufenjilipingtailizhihehuo、yinlingshengwuyouxiangongsijileads tech limitedgenjutamendinglideyizhixingdongrenshixieyi,youquanxingshigongsihegongyue20.08%detoupiaoquan。

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IPO雷达|创新药企维立志博拟赴港上市:两年半累亏逾8亿元,报告期内仅神州百济一家客户

zichengliyilai,gaigongsilianxu8lunrongzi,hejirongde10.84yiyuanzijin。

图片来源:界面图库

界面新闻记者 | 郭净净

jinqi,nanjingweilizhiboshengwukejigufenyouxiangongsi(jiancheng“weilizhibo”)dijiaogangjiaosuozhubaniposhangshishenqingcailiaohuoshoulibingpilu。12yue8ri,gongsixuanbu,jinyibuweirenzhaoyinguojirongziyouxiangongsiweiqizhengtixiediaoren。

weilizhibocheng,gongsicicigangguipomuzijiangyongyugongsilinchuangjieduanhouxuanyaowuzhengzaijinxingjijihuajinxingdelinchuangkaifajijianguanshiwu,biruhexinchanpinlbl-024dechixulinchuangkaifajijianguanshiwutigongzijin;weigongsiguanxianzhongqitalinchuangjieduanhouxuanyaowu(tebieshizhuyaochanpinlbl-034)dechixulinchuangkaifajijianguanshiwutigongzijin;tuijinjikuozhanxianyouguanxianjiyouhuajishupingtai;jiangyuhouxuanyaowuhuopizhunxiaoshouhouyongyuqishengchan、xiaoshoujishichangtuiguang;yongyuyingyunzijinjiyibanqiyeyongtu。

旗下12项创新候选药物均处于临床阶段

weilizhiboyu2012nianchengli,shiyijialinchuangjieduanshengwukejigongsi,zhiliyuzaizhongliu、zishenmianyixingjibingjiqitazhongdajibingfangmiandechuangxinliaofafaxian、kaifajishangyehua,gongsiyijianlicongzaoqishaixuanjifaxian、linchuangqianyanjiu、linchuangkaifa、cmcdaozhongshishengchandezhenggeyaowukaifaguochengzhongdesuoyoujibengongneng。

zhaogushuxianshi,weilizhibochuangxinguanxianbaokuo12xiangzhuyaozichan(chuangxinhouxuanyaowu),qizhong6kuanyijinrulinchuangjieduan,baokuo1kuanhexinchanpinji3kuanzhuyaochanpin;fenbieweizhenduizhongliude3kuandankelongkangti、4kuanshuangteyixingkangti、2kuankangtioulianyaowu(adc)ji1kuanshuangteyixingronghedanbai,yijizhenduizishenmianyixingjibingde1kuanshuangteyixingronghedanbaiji1kuansanteyixingkangti。

zaizhei12kuanchuangxinhouxuanyaowuzhong,6kuanyichenggongjinrulinchuangjieduan,gaigongsizhengdandujinxinghegong10xianglinchuangxiangmupinggu。qijinweizhi,gongsiyou2kuanhouxuanyaowuyu3zhongshiyingzhengdeiiqilinchuangshiyanzhonghuodegainianzhengming,qiegaidenghouxuanyaowuzhongyou1kuanjinzhanzhiguanjianxinglinchuangshiyanjieduan。

图片来源:维立志博港股招股书

qizhong,weilizhibodehexinchanpinlbl-024shiyikuanchuyuguanjianxinglinchuangjieduandexinxingpd-l1yu4-1bbshuangteyixingkangti。gongsimuqianzhengzaipinggulbl-024(zuoweidanyaoliaofajilianheliaofayibufen)duiyuzhiliaowanqifeiwaishenjingneifenmiai、xiaoxibaofeiai、dandaoai、feixiaoxibaofeiaijiqitashitiliudeliaoxiao。

gaigongsitoulu,lbl-024yiyu2024nian7yuejinruzhenduifeiwaishenjingneifenmiaidedanbeiguanjianxinglinchuangshiyan,shiquanqiudadaoguanjianxinglinchuangshiyanjieduandeshoukuan4-1bbbaxianghouxuanyaowu。lbl-024yiyoukenengchengweizhiliaofeiwaishenjingneifenmiaideshoukuanhuopiyaowu。

ciwai,weilizhiboyu2024nian10yueziguojiayaopinjianduguanliju(nmpa)huodelbl-024zhiliaohouxianfeiwaishenjingneifenmiaidetupoxingliaofarending(btd),bingyu2024nian11yuezimeiguoshipinyaopinjianduguanliju(fda)huodelbl-024zhiliaoshenjingneifenmiaidegueryaorending(odd)。

gaigongsijihuajinyibuyanjiuqiduiqitayaowukuifadeaizhengshiyingzhengdezhiliaoqianli,lirushiguanlinzhuangxibaoai、weiaijiganxibaoai。jiuyouguanguanjianxinglinchuangshiyandelinchuangjinzhanerding,gongsiyouwangzhi2026niandisanjiduxiangnmpatijiaoshengwuzhipinxukeshenqing(bla),yujizhi2027niandierjiduhuodeyoutiaojianpizhun。

weilizhibozhuyaochanpinlbl-033weitongshibaxiangmuc16jicd3deshuangteyixingtxibaoxianjiekangti。gaichanpinzhengbeikaifayongyuzhiliaomuc16gaobiaodadeshitiliu,tebieshiluanchaoai、gongjingaijizigongneimoaidengfukeaizheng。genjufuruositeshaliwenziliao,lbl-033yijishenquanqiujinyoudeliangkuanyijinrulinchuangjieduandemuc16/cd3shuangteyixingkangtizhilie。gongsifenbieyu2023nian2yueji2023nian6yuehuodenmpajifdadeindpizhun,yu2023nian4yuezaizhongguokaizhanlbl-033danyaoliaofazhiliaowanqishitiliudei/iiqiyanjiu。

lingjujieshao,weilizhibodelingyizhuyaochanpinlbl-007weibaxianglag3dequanrenyuanigg4dankelongkangti。genjufuruositeshaliwenziliao,gaichanpinweiquanqiulinchuangjinduqiansandebaxianglag3delinchuangjieduandankelongkangtizhiyi(weiyishangshidelag3baxiangyaowuchuwai),yiweitongleikangtizhongshoukuanbeizhengshiduibiyanaiyouxiaodekangti。

积极商业化变现,签约百济神州等3家公司

weilizhibozhichu,suizhegongsihouqilinchuangzichanjiejinshangyehuashangshi,qikenenghuikaolvjianlijushangyeguimodeshengchansheshi,bingtouguohezuojineibuxiaoshoutuanduijiaqiangshangyehuanengli。tebieshi,gongsizhengzaijijixunqiuyutoubuxingyecanyuzhejichuangyetouzijianlizhanlvehezuohuobanguanxi,yitansuozhongguoyiwaidelinchuangkaifajishangyehuajihui。muqian,gaigongsiyijingyubaijishenzhou、hangzhoubaikaishengwuyiyaoyouxiangongsi、oblenio bio,inc.dengdinglihezuoxieyi。

yu2021nian12yue,weilizhiboyubaijishenzhoudinglishouquanjihezuoxieyi。gaigongsiyishouyubaijishenzhouzaidazhonghuaquyiwaikaifa、shengchanjishangyehualbl007dedujiaxuke,daijiaweizongjigaoda7.72yimeiyuandeshoufukuanjilichengbeifukuan,lingjiashuangweishubaifenbidefenjitexuquanshiyongfei。tongguoyubaijishenzhouhezuo,lbl-007muqianzhengyuzhongguojiquanqiujiuduozhongaizhengshiyingzhengjinxingiiqilinchuangshiyan,baokuofeixiaoxibaofeiai、jiezhichangai、toujingbulinzhuangxibaoai、shiguanlinzhuangxibaoaijibiyanai。

lingjuweilizhibojieshao,yu2023nian4yue,gaigongsiyuaizhengchuangxinadcyaowugongsihangzhoubaikaishengwuyiyaoyouxiangongsi(liantongqiruoganhaiwailianshugongsi,tongcheng“baikaiyiyao”)dingliadchezuokaifaxieyi,yiliyongbaikaiyiyaozhuanyoudeadcyouxiaofuzailianjieqipingtaijixiangguanzhuanyoujishu,gongtongkaifalbl-013jiqitaliangxianglinchuangqianadczichan。

yu2024nian11yue,weilizhiboyushengwujishufengxiantouzigongsioblenio bio,inc.dinglihezuo、dujiaxuanzequanjixukexieyi。gongsiyiyiyuaditum biojiuxinchenglideyijiameiguogongsinewco,zhiliyugongsitedingsanteyixingtcellengagerdequanqiukaifajishangyehuadachenghezuoanpai,jiaoyizongjiazhigaoda6.14yimeiyuan,lingjiaqianzaizhonggeweishutexuquanshiyongfeijiyunewcodeguquan。genjuxieyi,weilizhiboshouyunewcoqilinchuangqianzichanlbl-051(yikuancd19/bcma/cd3 tcellengager)dujiaquanqiuxuke,newcokexuanzeyushiyongxuanzeqihouxingshiqixuanzequanbaoliuyouguanxuke。

两年半累亏8.23亿元,成立以来募资10.84亿元

weilizhibomuqianbingwuchanpinhuozhunjinxingshangyexiaoshou,yiweizichanpinxiaoshouchanshengrenheshouru。yuwangjijiluqijian,gaigongsishangweiludeyingli,bingcunzaiyingyunkuisun。caiwushujuxianshi,2022nian、2023nianji2024nianqian6yue,weilizhiboqineikuisunfenbieshi2.81yiyuan、3.62yiyuanji1.8yiyuan,liangnianbanleijikuisun8.23yiyuan。

图片来源:维立志博港股招股书

yuwangjijiluqijian,gaigongsijinyoubaijishenzhouyimingkehu;yu2023nian,genjubaijishenzhouxieyi,gongsijiujinxingyouguanqiaojieyanjiuzibaijishenzhoushoudaokuanxianggong890wanyuan。yu2022nianhuojiezhi2024nian6yue30rizhiliugeyue,gongsibingwuchanshengrenheshouru。

weilizhibobiaoshi,qiyuhendachengdushangyilailinchuangjieduanjilinchuangqianjieduanhouxuanyaowudechenggong。tanggongsiwufachenggongwanchenglinchuangkaifa、qudejianguanpizhunjishixianhouxuanyaowushangyehua,huotangyujinxingrenheshangshushixiangshizaoyuzhongdayanwuhuochengbenchaozhi,gongsideyewu、caiwuzhuangkuang、jingyingyejijiqianjingjianghuiyanzhongshousun。

gaigongsiyuqijiezhi2024nian12yue31rizhiniandujiangjixuludekuisunjinge。weilizhibobiaoshi,yujiyukeyujianweilaijiangjixuchanshengkuisunjinge,qiekenengwufachanshengchongzushouruyishixianhuoweichiyinglinengli;weilaijingkuisundejinejiangbufenqujueyuyanfaxiangmusuochanshengdechengbenjiyuyingyunyouguandekaizhidaozhideweilaizhichu、renhehuopichanpindeshangyehuachengben、chanshengshourudenengliyijigongsiyuhuotouguoyudisanfangdeanpaizuochuhuoshouqudelichengbeijiqitafukuandeshijianjijine。

2022nian、2023nianji2024nianqian6yue,weilizhibodeyanfakaizhifenbieshi1.85yiyuan、2.31yiyuan、8399.9wanyuan,qizhonghexinchanpinyingzhandeyanfakaizhifenbiewei1390wanyuan、6870wanyuan、3360wanyuanji2700wanyuan,fenbiezhantongqizongjingyingkaizhide6.7%、25.6%、25.4%ji18.9%。

lingjuzhaogushu,2022nian、2023nianji2024nianqian6yue,weilizhibodeliudongfuzhaizongefenbieshi12.26yiyuan、13.95yiyuanji2.18yiyuan,qimoxianjinjixianjindengjiawufenbieshi2.53yiyuan、2.48yiyuanji2.74yiyuan,jingyinghuodongsuoyongxianjinjingefenbiewei4369.2wanyuan、1.93yiyuanji1.07yiyuan。

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