文 | 氨基观察

shizhijinri，tongjingyiranmeiyouduizhengdeyaowukeyong。

jinguanzaishehuiguannianzhong，tongjingbeishiweinvxingdexunchangzhitong。henduonvxingxuanzerenyirenhuoshizhitongyaolaiaoguojingqitengtong，yehenshaoyourenweicitedijiuyi。

raner，tongjingbingfeizongshiwuhaide，zheizhongyinrenyoukenengmaizangzhejidayinhuan。

tongjing，youqiyanzhongdetongjing，henkenengshiyizhongbing——zigongneimoyiweizheng。zigongneimoyiweizhengyuanbuzhitongjingneimejiandan，bujinkeyiqinxizhouweizuzhiheqitaqiguan，daozhifuzadezhengzhuang，hairongyizaizhiliaohoufanfufazuo，zhidaojuejinghoucainenghuanjie，jihuanzhedailaiwujindetongkuzhemo，shenzhibeijiaozuo“busideaizheng”。

zaizheibeihou，yuanyinguranshiduofangmiande。biru，cuowude、guhuadeshehuiguannian；biruwulunhuanzhehaishiyihurenyuan，duizigongneimoyiweizhengjunquefazaozhenduan、zaozhiliaodeyishi；zuizhongyaodeshi，youyuqueqian、queshujudengzhongzhongyuanyin，yaoqixianshaotazuzheiyilingyu，zheiyedaozhilinchuangshangyizhiquefayouxiaozhiliaoshouduan。

zigongneimoyiweizhengdechujing，huoxuyezhishiwanqianjibingzhongdebingshanyijiao，zheiyeshikejijinbuchangmingxiadeyinanmian。

erzheizhongcuozongfuzadejumian，yehennanzaiyixizhijiandedaochediniuzhuan。

danshi，womenyiranbaochiqidai。dangyuelaiyueduonvxingyishidaobushufuxuyaobeikanjian，dangzigongneimoyiweizhengzhubudedaozhongshi，xindebianhuajiujiangyunyuersheng。

01 “不死的癌症”

zigongneimoyiweizheng，shiyizhongyouzigongneimotuolizhengchangweizhishengzhangeryinqidejibing。

jiandanlaishuo，zigongneimoxibaoyuanbenshi“juzhu”zaigongqiangneinianmocengshang，zaici、yunjisudediaokongxiafashengzhouqixingdegaibian。takenenghuidingqituoluo，hunjiyujingxuepaichutiwai，yekenenghuichengweishoujingluanfayudewenchuang。

danshi，bufen“panni”dezigongneimotaolilegongqiang，zaipenqiangfumo、luanchao、zigongbiaomianyijigongdirendaidengbuwei“anyingzhazhai”，yinfayixiliebushizhengzhuangyijibulianghouguo。

zuoweineiyizhengzuizhuyaodelinchuangbiaoxian，tongjing，jiushishentifachudeqiujiuxinhao。

dangran，zigongneimoyiweizhengyuanbuzhitongjingneimejiandan，bujinkeyiqinxizhouweizuzhiheqitaqiguan，daozhifuzadezhengzhuang，hairongyizaizhiliaohoufanfufazuo，zhidaojuejinghoucainenghuanjie。zheizhongyemanshengzhang、nanyigenzhidetexing，yijitadaijihuanzhedetongkuzhemo，rangqibeijiaozuo“busideaizheng”。

zuoweiyizhongfuzadejibing，zigongneimoyiweizhengyingxiangzhequanqiuxuduofunv。youliuxingbingxuediaochaxianshi：yue10%deshengyuqinvxinghuanyouzigongneimoyiweizheng，shijiefanweineidehuanbingrenshukenengjiejinshenzhichaoguo2yi，yazhoudefabingrenshuchaoguoqitagedazhoudezonghe。

zhenshideshujukenenghuigenggao。shijieweishengzuzhidezigongneimoyiweizhengzhuantizhongtidao，yixiediqudegongzhonghebufenyiwurenyuanquefaduizigongneimoyiweizhengzaozhenduan、zaozhiliaodeyishi，henduorendouyiweitongjing、penqiangtongshibixurennaidezhengchangguocheng，yincidanwulejizaojiuyihezhenliao。

huanzhecengmianyeshiruci，duitongjingzhongshibuzu，yeshidaozhineiyizhengyanchiquezhendezhongyaoyuanyin。

ciwai，neiyizhengdeyanchiquezhen，yeyuqiquefayouxiaodewuchuangxingzhenduanfangfayouguan。yiwanglinchuangshang，tongchangzhinengjiezhufuqiangjingshoushuzhijieguanchazigongneidezuzhilaizhenduan。zheizhongfangshisuibeishiweineiyizhengzhenduande“jinbiaozhun”，danquehuizaochengchuangshang，chengbentaida。

ciwai，chaoshengjianchasuiranyeshineiyizhengdezhuyaojianchashouduan，danqizhunqueduyouxian；lingyizhongzhenduanfangshishifukechati（shuanghezhen、sanhezhen），nenggougenjubingbiandeweizhizhunqueshibieneiyizheng，youqishishenbujinrunxingneiyizheng。

raner，chatidejieguoyuyishidejingyan、jianchajiqiaoyouhendaguanxi，bingfeisuoyouyishengdounengshulianzhangwo。

02 研究负循环

shizhijinri，shangmeiyouchedizhiyuzigongneimoyiweizhengdebanfa，suoyoudezhiliaoshouduandadoushiweilekongzhihuohuanjiezhengzhuang。zuichangjiandejiushifuyongzhitongyao，yijijisuleibiyunyaowudengyizhibingzaofazhan，yanzhongdeqingkuangkenengyaozhuanxiangshoushu，qiechuzigongneimoyiweizhengyinqidebingbian，shenzhiwanquanqiechuzigong。

tongchangqingkuangxia，huanzheguimopangda、zhiliaoshouduankuifa，yiweizheshangyehuaqianjingguangkuo，wangwanghuixiyinyaoqideyanfabuju。danzheiyidian，zaizigongneimoyiweizhengzheili，sihubingbuchengli。

yifangmian，zairenhetiaojianxia，kaifayaowudoubushiyijianrongyideshi。youqishidangduijibingmeiyouhenhaodelejieshi，zheigeguochenghuigengjiakunnan。

zhijin，zigongneimoyiweizhengdefabingjizhishangweimingque。

yixuejieyouyixielilunnengbufenjieshizigongneimoyiweizhengdefasheng，zuiliuxingdelilunshi1927niansampson tichudezhongzhixueshuo。gaixueshuorenweishigongqiangneidezigongneimopiaoliudaoqitabuweibingzhongzhilexialai，xingchengleneiyizhengdebingzao。

weijingqidefuqiangjingjianchafaxian，90%denvxingdouyoujingxuenixingdexianxiang，danfashengzigongneimoyiweizhengdezhishihenshaoyibufenren。zheiyiweizhechuleneimodeqianyizhiwai，huoxuhaiyouqitayinsucanyulebingzaodexingcheng，rujiyintubian、mianyigongnenggaibian、neifenmixinhaoyichangdeng。

huanjuhuashuo，jibianyouxielilunkanqilaihenheli，yerengranwufajieshihenduowenti，zheishidezigongneimoyiweizhengdechengyinzhijinshangweimingxi，ziranyenanyigenjubingyincaiquxiangyingdeyufangzhiliaocuoshi。

lingyifangmian，xinxichizi，shixiangguanyaowuyanfakuifadeguanjianyuanyin。

yanjiurenyuanyoushihuishiyongshengwuku——congzuzhi、xueyehednayangbenzhongshoujiyixueheshengwushuju——laishibiejibingdefenzibiaozhiwu，huokaifayouxiaodezhenduanfangfa。ruguoyouzhengfuzizhudexiangmushouji，shujutongchanghuifabuhuotigongjikexuejia，weiyaowuyanjiutigongleqidian。

danshi，anzhaobeileyixueyuanfuchankefujiaoshoujianlinchuangyishengbaburekhejoseph nassifdeshuofa，zheizhongziyuanzaizigongneimoyiweizhengzhongshifenyouxian。dangran，gaibianzhengzaifasheng，meiguozhengzaishituweisuoyouhuanyouzigongneimoyiweizhengdehuanzhezuoyigeshujuku。

shishishang，zheizhongxinxibuzugenshendigu。90niandaimo，fdahaijianyijiangyulingfunvpaichuzaicanjiadi1jieduanhedi2jieduanlinchuangshiyanzhiwai，jishitamenshiyongdeshibiyunyaoju。zheixiezhengceshiweileyingduiyaowushaliduanyinqidechushengquexianerzhidingde。

1993niandeyixiangfalvyaoqiujiangfunvheshaoshuminzunarumeiguoguojiaweishengyanjiuyuanzizhudelinchuangyanjiuzhong，danshizuzhifunvcanyushiyandexiaoguo，yizhiyanxudaojintian。

2022niandeyixiangyanjiufaxian，zai2016nianzhi2019nianqijian，meiguojinxingdeyaowuheyiliaoshebeidi1zhidi3jieduanshiyandecanyuzhezhong，nvxingzhan41%。yunvxingzaixinzangbinghejingshenzhangaidengyixiejibingzhongzhanzonghuanzherenkoudebilixiangbi，nvxingcanyulinchuangdedaibiaoxingyuanbuzu。

zheixieyanjiuchajuyijitamenkenengzaochengdelinchuangxinxi、ziyuanbuzu，zuizhongshinvhai、funvchuyu“judalieshi”。

zheirangshiqingxianruleyigefuxunhuan，jinguanzheizhongjibinghenpubian，danrenmenduitalejieshenshao。

03 药企的撤退

dangran，yiqiedegenyuanhuoxuhaiyaozhixiang，qian。zigongneimoyiweizhengyanjiuzijinfeichangbuzu，yaoqiyehenshaoshezuzheiyilingyu。

shishishang，yuqitayaowuyanfalingyuxiangbi，nvxingjiankangrengranzijinbuzu。duimeiguoguoliweishengyanjiuyuanzhichideyanjiudefenxifaxian，zhuyaoyingxiangnanxingdejibinghuodelegengduodezijin。zhuyaoyingxianghuodetouzidefunvdejibingtongchangzaizhongliuxuelingyu，ruruxianaiheluanchaoaiyijishengzhiyixue。

硅谷银行的数据则显示，2019年，美国和欧洲在3225笔生物制药交易中投资了1220亿美元，这其中，只有13亿美元投资于女性健康生物制药公司。

quefazijin，shidaozhishengwujishugongsitingzhiyanjiuhouxuanyaowuhuoyouxiankaolvqitaxiangmudezhuyaoyuanyin。

yucitongshi，pangdadeweimanzudelinchuangxuqiu，yuzuizhongdeshangyehuibaobuchengzhengbi，yejidadiyingxiangzheyaoqidetourureqing。

zuichubeipizhunyongyuzhiliaoqianliexianaidejisuliaofalupron depot，zaimeiguobeipizhunyongyukongzhiyuzigongneimoyiweizhengxiangguandetengtong。

guoqushinianli，fdahaipizhunlelingwailiangzhongyongyuzigongneimoyiweizhengtengtongguanlidechanpin：2018niandeaiboweideorilissa，yiji2022niandehuiruihehezuohuobanmyovant sciencesdemyfembree。

raner，zheixieyaowudejiagehengao，orilissahemyfembreemeiyueangezidebiaojiajisuanchaoguo1000meiyuan。tamenyewufaconggenyuanjiejuejibing，qieyouyuyoukenengjiangdigumidu，zuiduozhinengshiyongliangnian。

zhengyinci，orilissahemyfembreedexiaoshouebingbulixiang。qizhong，orilissazaihuopisannianhou，aiboweihaicengshituchushougaiyaowusuozaidefunvbaojiandanwei，danjiaoyibingweishixian。zheikuanyaowudexiaoshoueyebuzaidandubaogao，ershiyuaiboweicaibaozhongde“qitaguanjianchanpin”yiqihuizong。

aiboweishangyicibaogaoorilissadejingshourushizai2021cainian，dangshiqizaimeiguodexiaoshoueshi1.39yimeiyuan。

jishishidayaoqi，chuyuhuibaodekaolvyebudebuzhuanerzhuiqiuqitalingyu：baiercengshifunvjiankanglingyudezhuyaocanyuzhe，quniantabiaoshijiangbazhongdiancongfunvjiankangzhuanyidaomianyixue、hanjianjibingheshenjingxue。

baierzhangqiyilaiyizhizaixiaoshouyizhongmingweivisannedejisuyaowu，yongyuzhiliaozigongneimoyiweizhengxiangguantengtong。qihaiyumeiguoheyingguodeyanjiurenyuanhezuo，bangzhushibielekenengyuzigongneimoyiweizhengxiangguandeyanzhengjiyin。baierfayanrenbiaoshi，suiranzheiyifaxiansihuzhixianglekenengdefeijisuyaowubadian，danjinyibudeyanjiu“zuizhongbingmeiyoutuijinkaifa”。

genjulutoushedebaodao，yuanyinshibaierzainvxingjiankanglingyudezongtigongzuo，“meiyoudadaoyuqi”。

04 总结

zigongneimoyiweizhengdechujing，huoxuyezhishiwanqianjibingzhongdebingshanyijiao。

bijing，rentishishenmieryoufuzadezuzhi，erxiangguanjibingjizhi、linchuangshujudequeshi，gengshirangwomenduizhongduojibingderenshiyirankuifa，zheiyeshikejijinbuchangmingxiadeyinanmian。

jiashangguyou、cuowudejibingshehuirenzhi，yehuijinyibuzuaixindebianhuafasheng。

danshi，womenrengyaobaochiqidai。cuozhehefengxianyizhidoushixinyaoyanfalushangdechangke，zheibingbuhuigaibianxinyaoxiangqiandequshi。kaichuangxingdeyanjiuwangwangshijishuchufadian，daozhilexinyaoyanjiudebaozhashizengzhang。

wulunzigongneimoyiweizhenghaishiqitajixuxindezhiliaoshouduandejibing，douzaidengdaizheiyangyigechufadian。