文 | 氨基观察

guoquzheiyinian，cnslingyudabaofa，jingshenfenliezhengyinglaipobing，aerzihaimozhengzaiyingzhongbangxinyao……

dayaoqiduiyuzheiyilingyudereqing，gengshikongqian，10yimeiyuanyishangdehezuo，jieerliansan。raner，yuxianhua、zhangshengxiangbande，haiyouwufabaituodecuozheyushibai。

youqiaibowei，11yuefen，jiujinglilesancilinchuangshibai，zaijingshenfenliezhenglingyudezhongbangyazhu，conggaodianzhijiediaotouxiangxia，zhuanshunchengkong。

2024niandecnslingyukaiqileguoshanchemoshi。dangran，baokuokarxtdengzaineideneixietupoxingxinyaodewenshi，yiranrangzheichangguoshanchezhilvchanshengdecijiduoyudianbo。

buguo，zheizhongquzhe，yiranshifenqingxiditixingzhewomen，danaoshiyigeduomefuzayoujingmideheixiazi。erduizengzhangdekewang，yijiugulizheyaoqizaizheiyilingyuchixutansuo，wushishibai、qianfuhouji。

01 精神分裂症的火焰与海水

yibanhuoyan，yibanhaishui。

9yue26ri，jingshenfenliezhenglingyuyinglailishixingyike，karunayanfadekarxthuodefdapizhunshangshi。

zheishi35nianlaishoukuanjingshenfenliezhengxinyaodewenshi，yeyanzhenglequniandi，baishimeishiguibaoyi140yimeiyuanshougoukarunajuecedezhengquexing。

duibizhixia，yubaishimeishiguibaoqianhoujiaochijuzishougoucerevel，yazhucnsdeaibowei，quebeitouzizhezhiyiyanguangqianjia。

jiuzai11yue11ri，aiboweixuanbushougoucereveldedaode“wangpaixiangmu” emraclidine，weinengzailiangxiangzhenduijingshenfenliezhengdeiiqiyanjiuzhongdadaoyuqizhongdian。xiaoxiyichu，aiboweigujiabaodie12.57%，yiyezhijianshizhizhengfa400duoyimeiyuan。

emraclidinehekarxtyuanbendejubenxiangsi，doushibeidayaoqikanzhongdejingshenfenliezhenghexinzichan，qiedoushiduxunjianshouti，bishidebutongdianshi，qianzhezhizhenduim4shouti，houzhezezhenduim1、m4shouti。

dangran，rujinzuidadebutongshi，erzhedejiejujieranxiangfan。jinguanaiboweichengnuojiangjixufenxishuju，danrengyoubushaotouzizherenwei，cicishujuchuluzhihou，aiboweiduobanhuifangqiguanxianyijieshengziyuan。

yucitongshi，baishimeishiguibaozegongbulekarxtzhangqiyanjiujijishuju。zheijinyibuzhengshiqinenggouweijingshenfenliezhengzhiliaodailaixianzhudegaibian。

liangxiangduibizhixia，aibowei87yimeiyuanshougouanbeizaicituizhifengkoulangjian，shenzhizhiyiqizhangqishenjingbankuaibujudezhanlve。mianduizhiyi，aiboweibiaoshi，“zheijiagongsi（cerevel）deguanxianrengyougengduoqianli”。

yigeyuezhihou，aiboweixuanbucereveldelingyihexinguanxianpajinsenyaotavapadonzaiguanjian3qitempo-2shiyanzhonghuoyang，suanshiweigongsiwanhuilexiexu“yanmian”。

tavapadonshiquanqiushoukuanxuanzexingbaxiangduobaand1/d5shoutiyaxingdebufenjidongji，meiriyicikoufuzhiliaopajinsenbing。ciqianiiqiyanjiuxianshi，tavapadonkexianzhutigaoyundongjinengdeyundongzhangai-tongyipajinsenbingpingdingliangbiao（mds-updrs）diiiibufenpingfen，qieanquanxingyunaishouxingbiaoxianlianghao。

在最新的TEMPO-2 III期研究中，tavapadon组在治疗第26周时，MDS-UPDRS第II、III部分综合评分较显著降低（安慰剂组:-1.2；tavapadon组:-10.3；p<0.0001）。

aiboweiyujimingniandijiaoshangshishenqing，ruguotavapadonnenggoushunlishangshi，jiangyuqixianyouzhenduizhengzhuangxingdewanqipajinsenbingliaofaguanxianchengweihubu。

zhibuguo，zheibingbunenggaibian，aiboweizaiqizhongbangyazhudejingshenfenliezhengshichang，zuoleyichangguoshanche，bingfuchulebuxiaodedaijia。

02 阿尔兹海默症的喜与悲

xiabannian，chulejingshenfenliezhenglingyuzaishangyanguoshanche，aerzihaimozheng（ad）denglingyuyebuliwai。

7yue2ri，lilaixuanbu，fdayipizhundonanemabyongyuzhiliaozaoqiaercihaimobingdechengnianhuanzhe。sanqilinchuangshujuxianshi，yuanweijizuxiangbi，donanemabyanhuanlehuanzhe35%derenzhishuaitui，yiji40%derichanghuodongxiajiang。dancongshujulaikan，zheigejieguoyijingshirenleikaishitiaozhanaercihaimobingyilaizuihaodeyici。

jinguananquanxingwentibukehushi，danfdadulikexueguwenweiyuanyizhitoupiaotongguo，renweidangqianzhengjuzugoubiaominggaiyaoyouxiao、gaiyaoyichudayufengxian。

beihoudehexinshi，adkuxinyaokongchuangqiyijiu。ciqian，lecanemabjiuzaianquanxingheyouxiaoxingshangweiwanquanzhengshideqingkuangxia，jiyuqijiangdihuanzhedanaodianfenyangdanbaichenjidezhiliaoxiaoguo，huodelefdadejiasupizhun。

erzheijidajilizhehoulaizhe，jiaozhuzheiyiwanyishichang。

qizhong，alectoryuaiboweihezuokaifayongyuzhiliaoaddeal002，beihaiwaimeitipingwei2024niansijiduzhideguanzhude9xianglinchuangshiyanzhiyi。

zaozai2017nian，aiboweiyi2.05yimeiyuandeyufukuanhegaoda2000wanmeiyuandeqianzaiweilaiguquantouziyualectordachengxieyi，yongyukaifaheshangyehuaadhouxuanyaowual-002heal-003dequanqiuxuanzequan。

2022nian7yue，aiboweijuedingfangqial003，baoliual002dexuanzequan，qikanzhongdeshial002dezuoyongjizhi。al002baxianggusuixibaochufashouti2（trem2），trem2zuoweiyizhongkuamoshouti，zaiyibufenxiantianxingmianyixibaoshangbiaoda，bingzaixiaojiaozhixibaoshangteyixingdibiaoda，zheixiexibaogongtonggouchengdanaodemianyixitong，suizhetrem2gongnengdejiangdikenenghuidaozhiadheqitaxingshidechidaizheng。

raner，zheiyijizhizaililunshangdeqianli，bingmeiyouzaishijilinchuangzhongdedaoyanzheng。11yue25ri，alectorxuanbu，al002deiiqiinvoke-2yanjiushibai，meiyouxianzhujianhuanaercihaimobinghuanzhedelinchuangjinzhan。bingqie，al002duiaddeyetishengwubiaozhiwumeiyouxianzhuyingxiang，dianfenyangdanbaipetchengxiangxianshinaodianfenyangdanbaishuipingmeiyouyuzhiliaoxiangguandejiangdi。

jiyuci，alectorjuedingtingzhiduial002dezhangqikuozhanyanjiu，tongshijihuacaiyuanyue20%。stifel partnersfenxishichenginvoke-2dedushushialectorde“chedishibai”。erzaicizhiqian，fenxishirenwei，jiyuduimubiaodeqianglieyichuanheshengwubiaozhiwuzhengju，al002zaiaercihaimobingdeshiyanzhongyouhendadechenggongjihui。

meicuo，aiboweizaicizaicnslingyu，zuoleyiciguoshanche。dangran，jinnianyilai，zaiadlingyudeshiyizheyebuzhialectoryuaibowei。

jihutongyishijian，cassava sciencesgongsixuanbu，qibeishouzhengyideaercihaimozhengyaowusimufilamzaisanqilinchuangshiyanrethink-alzzhongshibai。yuanweijixiangbi，simufilamweinengjianshaoqingduzhizhongduaercihaimozhenghuanzhederenzhihuogongnengshuaitui。

gengzaoqian，cnsyaowukaituozhesagedehexinzaiyanguanxiandalzanemdoryezhejiad。jiashangcicilinchuangshili，jinnianlaidalzanemdoxianhouzaipajinsen、aercihaimobing、hengtingdunbinglingyuchangdaosancibaiji，gongsiyejuedingzhongzhiqiyanfa。

03 刺激多于颠簸

chucizhiwai，jiweisuocesuoyinghuazheng（als）yezai2024nian，jinglileyichangguoshanche。

2022nian，fdadingzheyalipizhunlealsxinyaorelyvriodeshangshishenqing，jinguandingjiagaoda15.8wanmeiyuan，alsyeshuhanjianbing，danrelyvirorengchuangzaoleyigeshichangqiji，2023nianxiaoshoueda3.8yimeiyuan。

relyviroyecengbeibushaorenshiweialshuanzhedejiuxing。raner，relyvriosuizaizaoqiyanjiuzhongzhanxianleyidingqianli，danzaigengdaguimo、gengzhangshijiandeshiyanzhong，qiliaoxiaobingweidedaochongfenyanzheng。

3yue8ri，amylyxxuanburelyvriozai3qilinchuangshiyanshibai，；4yue4ri，amylyxyexuanbulerelyvriotuishidejueding。

dangran，cnslingyuyebingbushimeiyouhaoxiaoxi。chulejingshenfenliezheng、adzheixiedashichang，yixiehanjiandeshenjingxitongjibingyezai2024nianyinglailetupo。

biru，3yuefen，fdapizhunleorchardkaifadejiyinliaofalenmeldy，zheishidiyizhongzhiliaobiansexingbaixibaoyingyangbuliangzheng（mld）dejiyinliaofa，mldshiyizhonghanjianqieweijishengmingdejitidaixiexitongyichuanxingjibing，genjuxianyouwenxiangujifashenglvyuewei1/10wanxinshenger。

6yuefen，fdapizhunleshoukuandushijiyingyangbuliang（dmd）jiyinliaofaelevidysdekuozhanshiyingzheng，jiangnianlingzhishaowei4suidedmdhuanzhenaruqizhong。wulunhuanershifounenggouxingzou，jinguangailiaofaduibukexingzoudehuanzhe，shangweiquerenshiyanzhongmanzuzhuyaoliaoxiaozhongdian；9yuefen，fdahaipizhunleshougezhiliaocxingniman-pikebingdeyaowumiplyffashangshi。

zongdelaishuo，cnsguoshanchezai2024nianchanshengdecijiduoyudianbo。

yucitongshi，suoyourendouqingchu，cnsxinyaokaifanandujuda，danlingyimianyedaibiaozheyaowuyanfadegaobileiyuyanzhongweimanzudelinchuangxuqiu，yidanyanfachenggong，chuangshoubukeguliang。

yinci，neixietupoxingxinyaodejielianchenggong，jilizheyaoqiwushishibai、qianfuhouji。

biru，suiransageshibaile，danhengtingdunlingyukaishikandaogengduodeqianyinli。prilenia therapeutics、wave life sciencesheuniquredouzaiguanzhupizhunkeyijiejuejibinggenbenyuanyindeliaofadetujing。

touziyezaizengjia。jinqi，nuohuayuptc therapeuticsgongsidachengjiazhijin30yimeiyuandehezuo，tuijinhouzhehengtingdunbinghouxuanyaowuptc518yanfa。jinnian，nuohuahaiyuvoyagergongsidacheng13yimeiyuanjiaoyi，tuijinhengtingdundengjibingdeyanjiu。

zaibiru，suiranadlingyudeshibailvjigao，danyaoqiyiranzaijiandingbuju。

bupashudeaibowei，10yuefenzaicichijuziyazhuaerzihaimozheng，yi14yimeiyuanshougoualiada，houzhedehexinzichanshialia-1758，muqianchuyulinchuangiqishiyankaifajieduandekangdianfenyangdanbaikangti。

wutianzeyi1yimeiyuanyufukuan+zuigao21yimeiyuanlichengbeikuan，nadaoac immunebaxiangyouduxingshidianfenyangdanbai（aβ）demianyiliaofa，baokuoyongyuzhiliaoaddeaci-24.060dequanqiudujiaxuanzehexukequan。

bojian/weicaidelecanemabhelilaidedonanemabzaiguoquliangnianzhongfenbiehuopi，chengweishoupizhenduiaercihaimobingdeaβdankangliaofa。xianran，qitadayaoqiyebuxiangcuoguozheiyikuaidadangao。

buguo，guoquyinian，zhenggelingyuguoshanchebandequzhe，yirantixingzhewomen，danaoshiyigeduomefuzayoujingmideheixiazi。

qidaiguowangjishiniandetansuoyushibai，nenggouweiwomentichuyigeyouyigecuowuxuanxiang，zuizhongtuidongzhenggexingyedejianjinjinbu，weigengduohuanzhedaiqushuguang。