jianzhongshichang，glp-1leiyaowufengtouwuliang。12yue10ri，《nature reviews drug discovery》qikanfabiaole2025nianquanqiuchangxiaoyaotop10yuce，shikuanyaowuzhongyousikuanshiglp-1leiyaowu，fenbieweisimeigelutaihetierbotaidetangniaobinghejianzhongchanpin。

simeigelutaihetierbotaidejianzhongshiyingzhengxianhouyu2024nian6yue、7yuezaiwoguohuopishangshi，shangpinmingfenbieweinuoheying、mufengda。guochanfangmian，renhuishengwuzizhuyanfadebeineilutaizhusheye（feisumei）yiyu2023nian7yuelvxianhuoguojiayaopinjianduguanlijupizhunshangshi，chengweiwoguoshoukuanfeipangzhengzhiliaoxinyao。

pengboxingyeyanjiuzhichu，quanqiuyou90duojiayaoqizhengzaiyanfajianzhongyaowu，qizhongyue30%weizhongziyaoqi，juedaduoshushijiyuglp-1dezhiliaofangan。zaisimeigelutaihetierbotaizaiquanqiusuoxiangpimidegejuxia，yibeineilutaiweidaibiaodeguochanglp-1xiangyaozaijianzhongshichangzhongfenshiyikuai“dangao”，zuizhonghaishiyaokaolinchuangjiazhishuohua。

bunankandao，jianzhongshuangxiongrengzaisijuan“jianzhongshuju”。2024nian 12yue4ri，tierbotaiyuanyanchangjiameiguolilaigongbuyixiangtouduitoushuju：zai72zhoushi，tierbotaidecanyuzhejiandiaole22.8gongjin，ershiyongnuohenuodesimeigelutaidecanyuzhejiandiaole15gongjin，tierbotaidekuaisujianzhongxiaoguogengshengyichou。12yue20ri，nuohenuodepanqiangujiayidudadiejin30%，chuangxialishishangzuidadanridiefu，zhiyinqifabiaodejianzhongyaocagrisemadehouqijianzhonglinchuangshujuweinengxianzhujibaitierbotai。

buguo，yeneizhichu，glp-1leiyaowuyanfafangmian，danchun“kuaisujiangditizhong”jiaoduyijingchuxianleshenmeipilao，erruhejiankang、zhangqidejianzhongyijiyougengshaodefuzuoyong、gengfangbiandejiyaodengshiweilaiyanfatupodefangxiang。yixiejianzhongyaowucunzaidedafufandan、jianji、kualiandengwenti，zhengzaiyinfadanyou。

jugongkaishuju，wulunshicaiyongsimeigelutaihaishitierbotaijianfei，yidantingzhiyongyaodouhuimianlintizhongfandandefengxian。biru，zaistep4shiyanzhong，simeigelutaitingyaohoudedi48zhou，canyuzhedetizhongfandanlejinsanfenzhier。tierbotaidesurmount-4linchuangshiyanyexianshi，tingyaohouhuanzhedetizhongmingxianshangsheng，pingjunfandanle14%。tizhongfandanhuixianzhuzengjiaxinxueguandaixiefengxian，bingdaozhimanxingyanzheng，yinfamanxingjibingfazhandengwenti，qianzaiweihaiburongxiaoqu。

erdafudujianjidailaideweihaigengjiayanzhong。yixianghuiguyanjiubiaoming，simeigelutaishoushizhejiandiaodetizhongzhong，jin40%weijirou，zheihuizengjiahuanxinxueguanjibing、guzhishusongzhengdefengxian。zaishengyuanshouxikexueguangeorge yanopoulosqiangdiao，jiroujianshaoshisimeigelutaihetierbotaideyigelingrendanyoudefuzuoyong。rubujiejuejiroukuaisuliushiwenti，jianfeiyaokenenghui“bidayuli”。

xiangxingzhixia，guochanyuanyanglp-1youshituchu。beineilutaikezaigengduanzhiliaozhouqineishixianjianzhongmubiao，yongyao3～4geyue，kejiangditizhong6～13%。beineilutaijianzhongduijirouyingxiangxiao，zaiyixiangqianzhanxing、suijiduizhaoyanjiuzhong，shiyongbeineilutaizhiliaodechaozhong/feipanghuanzhe，jianshaodetizhongdabufenweiquganzhifangjifubuzhifang，jiroujianshaojinzhanzongtizhongjianshaode16.5%。ertingyaotizhongfandanshaoshibeineilutailingyidayoushi，yanjiuxianshibeineilutaijiyao4geyuetingyao3geyue，fandanlvjinwei0.78%。

muqian，zaiquanqiuyishangshideglp-1leiyaowuzhong，beineilutaishiweiyiyikuanquanrenyuanchanpin，qianjisuanxulieherentichangdaoneifenmidejisuglp-1wanquanyizhi，tongyuanxing100%。simeigelutaidetongyuanxingwei94%，weiyanzhangyaowubanshuaiqijinxinglegaigou。

glp-1zheizhongjisujiuxiangge“shiyuguanjia”，weichizhetizhonghexuetangdezhixu，dangrenmenjincanshi，tajiuhuichulaigongzuo，tingzhijinshihou，tajiuhuibeimeijiexiaoshi。weilemonitianranglp-1zheizhongsuicanfenmidemoshi，beineilutaiyecaiquleyitiansancisuicanjiyaodefangshi。

zheizhongfangshibukebimianhuidailaitiyanganshangdebuzu——renhuishengwuyanfarenyuanzhengzaitansuobengjiyao、weizhentiejidengxinxingfangshijinxingshengji——danyerangbeineilutaigengjiafuhezhengchangrendeshenglijielv，chengweimuqianfuzuoyongzuishaodeyikuanglp-1leiyaowu。

zhongguochengrenchaozhonghefeipangdehuanbinglvchaoguo50%。zheiqizhong，duifuzuoyongmingandejianzhongrenqun，xiangyaojiankang、bufandanjianzhongderenqun，jiangshibeineilutaifahuiyoushidezhuzhendi。

lirudangxia，pingjiezaishengzhilingyudeanquanxingyoushi，beineilutaizhengjujiaofeipangdebeiyunqunti，zaiyuanneideshengzhi、fuchandengkeshijinxingzhongdianxueshutuiguang。beineilutaishiweiyiyikuanzaidongwushiyanzhongmeiyoufaxianshengzhiduxingdeglp-1，yanjiuzhengjuyixieru《duonangluanchaozonghezhenghebingyidaosudikangzhenzhizhuanjiagongshi》，kebangzhuduonangluanchaozonghezhenghebingfeipangdenvxingkuaisujianzhong，shixianhuaiyunmubiao。